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The Science

What is GHK-Cu?

GHK-Cu is a naturally occurring copper-binding tripeptide (Glycyl-L-Histidyl-L-Lysine) first isolated from human plasma in 1973. Native levels decline with age — supplementation has been studied for collagen synthesis, wound healing, and skin barrier restoration.

Mechanism

Activates fibroblasts, signals TGF-β1, modulates inflammatory cytokines, and supports antioxidant defense.

Peer-Reviewed

Over 100 published studies across dermatology, cosmetic chemistry, and regenerative medicine journals.

COA Verified

We publish a Certificate of Analysis for every batch — including potency, purity, and heavy-metal screening.

Selected Research

Peer-reviewed evidence

2015
BioMed Research International
GHK-Cu and skin remodeling: collagen synthesis and ECM restoration
Pickart L., Margolina A.
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2018
Cosmetics
Copper peptides in cosmetic formulations: stability and clinical efficacy
Pickart L., Vasquez-Soltero J.
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2012
Journal of Aging Research
GHK-Cu as a modulator of gene expression in aging skin
Pickart L., Vasquez-Soltero J., Margolina A.
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2020
International Journal of Molecular Sciences
Wound healing properties of copper tripeptide complexes
Park J., Lee S., et al.
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Radical Transparency

Every batch. Every COA.

We publish the Certificate of Analysis for every production lot — third-party assayed for active concentration, microbial limits, and heavy metals. Look up your batch number any time.

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